Traceability of Chemical Measurement Results

Traceability to recognised references, ultimately to the SI units, is an indispensable prerequisite for measurement results to be comparable and trustworthy and hence accepted worldwide. This holds also for chemical measurement results, particularly as these are often used as a basis for important decisions and agreements, for example in health care and environmental protection. The concept of traceability and the special problems associated with its application to chemical analysis as compared to metrology in general are described. Current approaches to establish traceability of chemical measurement results are reported. The most important development in the last two decades was the establishment of the Consultative Committee for Metrology in Chemistry under the Metre Convention, which provided the basis for an international reference framework for chemical measurements. In order to link up laboratory results anywhere in the world with this international reference framework, traceability structures on the national level are required. It is shown, using the demand for traceable chemical measurements in Germany as an example, how such structures can be established and efficiently used

Omega-3 Fatty Acids and Vitamin D in Cardiology

Dietary modification and supplementation play an increasingly important role in the conservative treatment of cardiovascular disease. Current interest has focused on n-3 polyunsaturated fatty acids (PUFA) and vitamin D. Clinical trial results on this subject are contradictory in many aspects. Several studies indicate that n-3 PUFA consumption improves vascular and cardiac hemodynamics, triglycerides, and possibly endothelial function, autonomic control, inflammation, thrombosis, and arrhythmia. Experimental studies show effects on membrane structure and associated functions, ion channel properties, genetic regulation, and production of anti-inflammatory mediators. Clinical trials evaluating a possible reduction in cardiovascular disease by n-3 PUFA have shown different results. Supplementation of vitamin D is common regarding prevention and treatment of osteoporosis. But vitamin D also seems to have several effects on the cardiovascular system. Vitamin D deficiency appears to be related to an increase in parathyroid hormone levels and can predispose to essential hypertension and left ventricular hypertrophy, increased insulin resistance, and eventually to atherosclerosis and adverse cardiovascular events. Randomized prospective clinical trials are needed to determine whether vitamin D and omega-3 FA supplementation therapy should be recommended as a routine therapy for primary or secondary prevention of cardiovascular disease

The MASCOT Magnetometer

The Mobile Asteroid Scout (MASCOT) is a small lander on board the Hayabusa2 mission of the Japan Aerospace Exploration Agency to the asteroid 162173 Ryugu. Among the instruments on MASCOT is a fluxgate magnetometer, the MASCOT Magnetometer (MasMag). The magnetometer is a lightweight ( ∼280 g∼280 g ) and low power ( ∼0.5 W∼0.5 W ) triaxial fluxgate magnetometer. Magnetic field measurements during the landing period and during the surface operational phase shall provide information about any intrinsic magnetic field of the asteroid and its remanent magnetization. This could provide important constraints on planet formation and the thermal and aqueous evolution of primitive asteroids.Thomas F. PetersonUnited States. National Aeronautics and Space Administration. Emerging Worlds Progra

Amount of substance and the mole in the SI

Abstract Following the revision of the International System of Units (SI), that takes effect on 20 May 2019, the unit mole is defined by using a fixed number of elementary entities. This number is the fixed numerical value of the Avogadro constant, which is the defining constant of the unit mole. This definition was made possible because the determination of the Avogadro constant had reached a level of relative uncertainty that allowed its value to be fixed and, at the same time, safeguard continuity of measurement results before and after the definition. The motivation for the revision of the SI and the mole in particular will be explained and the experimental work that allowed it is summarized

An AFM study on ferroelastic domains in lead phosphate, Pb3(PO4)2\mathrm{Pb_3(PO_4)_2}

The topography of the intersection of ferroelastic W domain walls with (100) surfaces of lead phosphate, , has been imaged with tapping mode atomic force microscopy (TMAFM). Spontaneous deformation of the ferrophase leads to a cleavage plane which forms a zig-zag profile along W domain walls. The predicted angle of between two adjacent domains on a (100) surface is confirmed by TMAFM observations. Surface deformation has no influence on this angle due to the dominance of the long-range spontaneous strain. Furthermore, W domains end as needle-like structures and TMAFM observations show that there is no detectable change in the local surface deformation in the vicinity of these needle tips

Novel Concept for the Mass Spectrometric Determination of Absolute Isotopic Abundances with Improved Measurement Uncertainty: Part 3 - Molar Mass of Silicon Highly Enriched in 28Si

A novel method of isotope amount ratio measurements using state-of-the-art techniques of a double focusing sector field mass spectrometer combined with isotope dilution mass spectrometry (IDMS) has been applied connecting analytical chemistry with metrology in chemistry aiming at the determination of the Avogadro constant (NA). The molar mass M(“Si28”) and the corresponding isotopic composition of an artificial silicon crystal material highly enriched in the 28Si isotope has been measured for the first time using a combination of a modified IDMS- and a multicollector-ICP-mass spectrometer (MC-ICPMS) technique. A value M(“Si28”) = 27.97697027(23) g/mol has been determined. This corresponds to a relative uncertainty urel = 8.2×10−9 (k = 1). From this silicon crystal material two 1 kg spheres were manufactured which are used by the International Avogadro Coordination (IAC) in order to reassess (NA) with an associated relative measurement uncertainty urel(NA) ≤1×10−8. The experiment presented here is the advancement and completion of parts 1 and 2 of this series of papers, describing the theoretical and general experimental applicability of the novel method. The current work summarizes the experimental findings aiming at the determination of the molar mass of the “Si28” material with the lowest uncertainty possible so far. The experimental prerequisites and bottlenecks for examining this highly enriched silicon material as well as experimental proofs for the verification of the presented results are described in detail. The experimental results are supplemented by an uncertainty budget according to the Guide to the Expression of Uncertainty in Measurement (GUM).JRC.D.4-Isotope measurement

Molar Mass of Silicon Highly Enriched in 28Si Determined by IDMS

The molar mass of a new silicon crystal material highly enriched in 28Si (‘Si28’, x(28Si) >99.99%) has been measured for the first time using a combination of a modified isotope dilution mass spectrometry (IDMS) technique and a high resolution multicollector-ICP-mass spectrometer. This work is related to the redetermination of the Avogadro constant NA with an intended relative measurement uncertainty urel(NA) less-than or equal to 2 × 10−8. The corresponding experimental investigations of the International Avogadro Coordination (IAC) were performed using this novel ‘Si28’ material. One prerequisite of the redetermination of NA is the determination of the isotopic composition and thus molar mass of ‘Si28’ with urel(M(‘Si28’)) less-than or equal to 1 × 10−8. At PTB, a molar mass M(‘Si28’) = 27.976 970 27(23) g mol−1 has been determined with an associated relative uncertainty urel(M(‘Si28’)) = 8.2 × 10−9, opening the opportunity to reach the target uncertainty of NA.JRC.D.4-Isotope measurement

Deglacial 14C data from three floating tree-rings and GICC05 ages

Radiocarbon dating is the most commonly used chronological tool in archaeological and environmental sciences dealing with the past 50,000 years, making the radiocarbon calibration curve one of the most important records in paleosciences. For the past 12,560 years, the radiocarbon calibration curve is constrained by high quality tree-ring data. Prior to this, however, its uncertainties increase rapidly due to the absence of suitable tree-ring 14C data. Here, we present new high-resolution 14C measurements from 3 floating tree-ring chronologies from the last deglaciation. By using combined information from the current radiocarbon calibration curve and ice core 10Be records, we are able to absolutely date these chronologies at high confidence. We show that our data imply large 14C-age variations during the Bølling chronozone (Greenland Interstadial 1e) - a period that is currently characterized by a long 14C-age plateau in the most recent IntCal13 calibration record. We demonstrate that this lack of structure in IntCal13 may currently lead to erroneous calibrated ages by up to 500 years